Associate Scientist II / Research Scientist, Physiology

Plato BioPharma, Inc (PBI), a growing pre-clinical contract research organization (CRO) supporting the pre-clinical research needs of the pharmaceutical and biopharma sectors, is seeking an Associate Scientist II / Research Scientist, Physiology with proven expertise in the physiology / pharmacology of the Cardiovascular and/or Pulmonary organ systems / therapeutic areas. This exciting position is for the accomplished “do-er” with strong applicable in vivo skills who wants to make an immediate impact by working in a small, exciting CRO where we focus on DOING science.  The position will provide hands-on experiences translating client research goals into executable study protocols that meet client needs.

Job Summary and Essential Functions

General Responsibilities

  • Design, manage and execute all aspects of conducting preclinical research on rodents including compound formulation, dosing, surgeries, functional evaluation and tissue collection.
  • Gains mastery of and becomes a leader in cardiovascular and pulmonary pre-clinical models of disease
  • Conducts directed and independent experiments and performs measurements of cardiac, hemodynamic, pulmonary and/or metabolic function in rodents.
  • Performs rodent cardiac and cardiovascular surgical procedures and functional testing including, but not limited to, myocardial infarction, cardiac I/R, radiotelemeter implantation, arterial and venous cannulation – both acute and chronic/survival; direct and indirect systemic hemodynamics, cardiac PV loops, organ and vascular bed blood flow measurements, cardiac ultrasound, ultrasonic large vessel Doppler flow measurements
  • Performs pulmonary functional testing including direct and indirect lung mechanic measurements
  • Responsible for collection, documentation, analysis and interpretation of data from experiments with ability to conduct in-depth statistical and correlative analysis to develop mathematical predictive models of disease and therapeutic intervention outcomes
  • Prepares results and conclusions of work, both in written and oral format, for delivery to clients and inclusion in technical reports.
  • Maintains in-depth knowledge of state-of-the art principles and theories and applies such knowledge to the research and business direction of the Company.

Project Involvement

  • Acts as a study principal investigator to achieve client commitments in communication, scientific expectations and contractual deliverables
  • Gains direct client services responsibilities over time
  • Responsible for overall study management and conduct of assigned studies including study timelines and quality standards.

People Management (if applicable)

  • Position may or may not manage one or more research associates depending on qualifications of candidate.
  • Demonstrates ability to manage scientific, operational, and administrative aspects of a team.
  • Directs the activities of Research Associates and may provide training to scientific staff in study-related standard operating procedures.
  • Establishes and maintains training and development objectives for direct reports
  • Performance management is required. Conducts annual performance appraisals and merit recommendations. Provides regular coaching feedback to team member on performance.

What we’re looking for:

  • The right candidate will demonstrate technical proficiency, scientific creativity and independent thought in participating in experimental design and recommending research strategy in a directed research setting.
  • Eagerness to be a leader both at and away from the bench
  • Possess excellent communication (both oral and written) and interpersonal skills
  • Must have strong organizational, planning and time-management aptitudes.
  • Exercises independent judgment in developing and standardizing methods, techniques and evaluation criteria for obtaining highly traceable, valid, and reproducible results.
  • Ability to participate, communicate and collaborate in an interdisciplinary team-oriented environment is essential.
  • Shows flexibility and ability to apply his/her knowledge to new areas of study.
  • Commitment to safety and the humane treatment of laboratory animals is required.

What we offer:

  • Paid Time Off and Paid Holidays
  • Medical, Dental, and Vision Insurance
  • 401(k) Retirement Savings Plan
  • Eligible for bonuses and pay increases dependent on personal and company performance
  • Personal growth opportunities through on the job experiences in a small growing business

Working Conditions:

  • Varies from typical office environment to a laboratory setting with direct exposure to/handling of laboratory animals
  • Non-standard hours and weekend work occasionally required
  • At times, may work with potentially hazardous substances
  • At times, work will require PPE (personal protective equipment)
  • Ability to perform repetitive tasks quickly and efficiently
  • Must be able to stand for long periods of time
  • Must be able to perform all physical aspects required of position including periodic lifting items up to 40 lbs. and moving racks or large items on wheels

Minimum Education / Experience Requirements:

  • PhD in an appropriate Physiological or Pharmacological discipline, and 3-7 years of relevant experience demonstrating expertise with sustained performance and accomplishments.
  • Biotech and/or Pharmaceutical industry experience highly desirable.
  • Requires verifiable experience in at least one of the following areas: cardiovascular, pulmonary or metabolism physiology, pathophysiology or pharmacology.
  • Rodent survival surgery experience in the cardiovascular, pulmonary or metabolism therapeutic areas
  • Technical proficiencies in cardiac ultrasound, indirect and direct hemodynamic measurements, arterial/venous cannulations and catheter placement, and/or indirect and direct lung mechanics (FlexiVent and whole-body plethysmography) highly desirable
  • Experience in the development of translatable rodent models of human disease and conducting in vivo efficacy studies according to study protocols.
  • Experience leading and motivating research associate staff is also a plus.

Job Type:

Exempt full-time 40+ hours a week

Qualified candidates interested in the position should send your resume and cover letter connecting your experience to the job requirements to Position title, level and compensation commensurate with experience. No phone calls and no recruiters, please.