Associate Scientist II / Research Scientist, Physiology

Plato BioPharma, Inc (PBI), a growing pre-clinical contract research organization (CRO) supporting the pre-clinical research needs of the pharmaceutical and biopharma sectors, is seeking an Associate Scientist II / Research Scientist, Physiology with proven expertise in the physiology / pharmacology of the Cardiovascular and/or Pulmonary organ systems / therapeutic areas. This exciting position is for the accomplished “do-er” with strong applicable in vivo skills who wants to make an immediate impact by working in a small, exciting CRO where we focus on DOING science.  The position will provide hands-on experiences translating client research goals into executable study protocols that meet client needs.

Job Summary and Essential Functions

General Responsibilities

  • Design, manage and execute all aspects of conducting preclinical research on rodents including compound formulation, dosing, surgeries, functional evaluation and tissue collection.
  • Gains mastery of and becomes a leader in cardiovascular and pulmonary pre-clinical models of disease
  • Conducts directed and independent experiments and performs measurements of cardiac, hemodynamic, pulmonary and/or metabolic function in rodents.
  • Performs rodent cardiac and cardiovascular surgical procedures and functional testing including, but not limited to, myocardial infarction, cardiac I/R, radiotelemeter implantation, arterial and venous cannulation – both acute and chronic/survival; direct and indirect systemic hemodynamics, cardiac PV loops, organ and vascular bed blood flow measurements, cardiac ultrasound, ultrasonic large vessel Doppler flow measurements
  • Performs pulmonary functional testing including direct and indirect lung mechanic measurements
  • Responsible for collection, documentation, analysis and interpretation of data from experiments with ability to conduct in-depth statistical and correlative analysis to develop mathematical predictive models of disease and therapeutic intervention outcomes
  • Prepares results and conclusions of work, both in written and oral format, for delivery to clients and inclusion in technical reports.
  • Maintains in-depth knowledge of state-of-the art principles and theories and applies such knowledge to the research and business direction of the Company.

Project Involvement

  • Acts as a study principal investigator to achieve client commitments in communication, scientific expectations and contractual deliverables
  • Gains direct client services responsibilities over time
  • Responsible for overall study management and conduct of assigned studies including study timelines and quality standards.

People Management (if applicable)

  • Position may or may not manage one or more research associates depending on qualifications of candidate.
  • Demonstrates ability to manage scientific, operational, and administrative aspects of a team.
  • Directs the activities of Research Associates and may provide training to scientific staff in study-related standard operating procedures.
  • Establishes and maintains training and development objectives for direct reports
  • Performance management is required. Conducts annual performance appraisals and merit recommendations. Provides regular coaching feedback to team member on performance.

What we’re looking for:

  • The right candidate will demonstrate technical proficiency, scientific creativity and independent thought in participating in experimental design and recommending research strategy in a directed research setting.
  • Eagerness to be a leader both at and away from the bench
  • Possess excellent communication (both oral and written) and interpersonal skills
  • Must have strong organizational, planning and time-management aptitudes.
  • Exercises independent judgment in developing and standardizing methods, techniques and evaluation criteria for obtaining highly traceable, valid, and reproducible results.
  • Ability to participate, communicate and collaborate in an interdisciplinary team-oriented environment is essential.
  • Shows flexibility and ability to apply his/her knowledge to new areas of study.
  • Commitment to safety and the humane treatment of laboratory animals is required.

What we offer:

  • Paid Time Off and Paid Holidays
  • Medical, Dental, and Vision Insurance
  • 401(k) Retirement Savings Plan
  • Eligible for bonuses and pay increases dependent on personal and company performance
  • Personal growth opportunities through on the job experiences in a small growing business

Working Conditions:

  • Varies from typical office environment to a laboratory setting with direct exposure to/handling of laboratory animals
  • Non-standard hours and weekend work occasionally required
  • At times, may work with potentially hazardous substances
  • At times, work will require PPE (personal protective equipment)
  • Ability to perform repetitive tasks quickly and efficiently
  • Must be able to stand for long periods of time
  • Must be able to perform all physical aspects required of position including periodic lifting items up to 40 lbs. and moving racks or large items on wheels

Minimum Education / Experience Requirements:

  • PhD in an appropriate Physiological or Pharmacological discipline, and 3-7 years of relevant experience demonstrating expertise with sustained performance and accomplishments.
  • Biotech and/or Pharmaceutical industry experience highly desirable.
  • Requires verifiable experience in at least one of the following areas: cardiovascular, pulmonary or metabolism physiology, pathophysiology or pharmacology.
  • Rodent survival surgery experience in the cardiovascular, pulmonary or metabolism therapeutic areas
  • Technical proficiencies in cardiac ultrasound, indirect and direct hemodynamic measurements, arterial/venous cannulations and catheter placement, and/or indirect and direct lung mechanics (FlexiVent and whole-body plethysmography) highly desirable
  • Experience in the development of translatable rodent models of human disease and conducting in vivo efficacy studies according to study protocols.
  • Experience leading and motivating research associate staff is also a plus.

Job Type:

Exempt full-time 40+ hours a week

Qualified candidates interested in the position should send your resume and cover letter connecting your experience to the job requirements to careers@platobiopharma.com. Position title, level and compensation commensurate with experience. No phone calls and no recruiters, please.