Small Animal Expertise & Technology

Minimizing variation within PBI research efforts is critical for generatingĀ interpretable data. Our team of scientists, small animal surgeons and animal care staff is trained on industry-leading surgical, instrumentation and animal husbandry techniques. Inter- and intra-operator variance is monitored to ensure reproducibility of data. Multiple quality control measures are captured and evaluated across all aspects of research project execution, giveing justification and confidence in all data provided. Internal self-policing systems keep our error rate at an extraordinarily low level.

PBI Core Small Animal Competencies

Initial Study Consultation Planning & Design

  • Consult with our experienced scientists
  • Power analysis for group size determination
  • Customized studies

Small Animal Surgery & Instrumentation

  • Well-rounded surgical techniques and approaches
  • Industry leading arterial catheter and vascular access placements

Compound Administration

  • Oral (p.o.), intraperitoneal (i.p.), subcutaneous (s.q.), intravenous (i.v.), intramuscular (i.m.), or intratracheal instillation (i.t.)
  • Once daily (q.d.), or twice daily (b.i.d.); any justified dosing paradigm

Longitudinal and Periodic Sample Collection

  • 24 hour urine collection
  • Timed, serial and endpoint blood collection
  • Gross morphological organ analysis, tissue biopsy, and histological & biochemical tissue processing

Animal Husbandry and Welfare

  • AALAS Certified Staff
  • 24/7/365 Facility Monitoring
  • Daily health observations
  • Palliative care

Necropsy

  • Comprehensive morphometric measurement
  • Full dissection and organ/tissue biopsy and collection

Data Auditing, Compiling, Graphing, Statistical Analysis and Reporting

  • All data audited for validity
  • Presentation ready graphs and slides
  • Parametric and Non-Parametric statistical analysis conducted asĀ appropriate
PBI Core In Vivo Technologies
  • Visual Sonics Vevo 770 Ultrasound
  • Radiotelemetry
  • Millar Pressure-Volume Catheter
  • Fluid Filled Catheter
  • Tail Cuff Blood Pressure
  • FlexiVent
  • Whole Body Plethysmography (non-invasive lung mechanics)
  • EKG
  • Inhaled Anesthesia
  • GFR & Renal Blood Flow by radiolabeled tracers
  • Blood Gas Analyzer
  • Metabolism Cages
  • Subcutaneous Vascular Access Ports
  • AD Instruments PowerLab Data Acquisition Platform
  • Automated Hematology Analyzer