Cardiovascular Disease & Injury

Cardiovascular disease is the leading cause of death worldwide. Cardiac dysfunction has a wide range of causes and clinical presentations, typically with a high degree of medical complexity. PBI studies cardiovascular disease in an integrative manner by evaluating physiological & biomarker parameters ranging from cardiac & systemic hemodynamics, renal function and ex vivo vascular function. Together, these data provide a detailed view of the clinical potential of test compounds.  PBI offers an array of cardiovascular disease and injury models, with many models reflecting the complex cardiovascular consequences of cardiac and renal injury.

Myocardial Infarction

Model Species Top Tier Data

Ischemia Reperfusion

Rat & Mouse

  • Infarction Index (Evan’s Blue / TTC Stain)
  • Echocardiography
  • cTNI
  • Serum Electrolytes, Glucose,
  • Cardiac Histology
  • Cardiac Gene Expression

LAD Ligation

Rat

Hypertension Based Cardiac Dysfunction, Hypertrophy & Failure

Model Species Top Tier Data

DOCA + Salt

Rat

  • Blood Pressure (Direct & Indirect)
  • Echocardiography (Cardiac Hypertrophy, LV dysfunction)
  • Creatinine Clearance, GFR
  • Urinary Protein, KIM1, NGAL, Osteopontin Albumin
  • Serum Creatinine, Bun, Electrolytes Triglycerides, Glucose, HbA1C
  • Kidney Histology (fibrosis, macrophage infiltration, α-Smooth Muscle Actin expression)
  • Kidney Gene Expression
  • Cardiac Histology (Fibrosis, macrophage infiltration)
  • Cardiac Gene Expression

Dahl Salt Sensitive

Rat

ANGII ± L-NAME

Rat

Spontaneously Hypertensive Rat (SHR)

Rat

5/6 NPX + NaCl (pole resection method)

Rat & Mouse

5/6 NPX (renal infarction method)

Rat

Cardiac Hypertrophy , Cardiac Pressure Overload & Heart Failure

Model Species Top Tier Data

Transaortic Banding (TAB)

Rat

  • Blood Pressure (Direct & Indirect)
  • Echocardiography
  • Creatinine Clearance, GFR
  • Urinary Protein, KIM1, NGAL, Osteopontin Albumin
  • Serum Creatinine, Bun, Electrolytes Triglycerides, Glucose, HbA1C
  • Kidney Histology (fibrosis, macrophages)
  • Kidney Gene Expression
  • Cardiac Histology (Fibrosis, macrophages)
  • Cardiac Gene Expression
  • cTnI

Isoproterenol

Rat & Mouse

Phenylephrine

Rat & Mouse

ANGII (±L-NAME)

Rat & Mouse

Myocardial Infarction (LAD Ligation)

Rat