Pulmonary Disease & Injury

An unmet need for effective treatments for pulmonary diseases represents a large burden on medical practice.  The initiation and progression processes are not fully understood for many pulmonary diseases. The prevalence of Obstructive Lung Disease (COPD, Airway Hyper-Reactivity), Restrictive Lung Disease (Pulmonary Fibrosis) and Pulmonary Arterial Hypertension (PAH) is increasing every year due to a multitude of factors as well as increased precision in diagnosis. PBI is a leader in pulmonary therapeutic development, offering an expanding portfolio of pulmonary disease models ranging from acute injury to fibrotic disease. In accordance with our integrative platform, concomitant right side heart remodeling and pulmonary hemodynamics are regularly evaluated to provide interpretable data to best represent human disease.

Pulmonary Fibrosis

Model Species Top Tier Data

Bleomycin

Rat & Mouse

  • Direct pulmonary mechanics (FlexiVent)
  • Indirect pulmonary mechanics (whole body plethysmography)
  • Blood Gas
  • Lung Histology (Fibrosis)
  • Lung Profibrotic & Proinflammatory mRNA expression
  • Right Ventricle mRNA Expression

Pulmonary Arterial Hypertension

Model Species Top Tier Data

Monocrotaline

Rat

  • Direct pulmonary artery hemodynamics
  • Direct pulmonary mechanics (FlexiVent)
  • Direct arterial hemodynamic
  • Blood Gas
  • Lung Histology (Fibrosis)
  • Lung Profibrotic & Proinflammatory mRNA Expression
  • Right Ventricle mRNA Expression

Acute Lung Injury

Model Species Top Tier Data

Lipopolysaccharide (LPS)

Rat & Mouse

  • Bronchoalveolar Lavage Fluid (BALF) cell differential, neutrophils & cytokines
  • Direct Pulmonary mechanics (FlexiVent)

Bleomycin

Rat

Airway Hyper-Responsiveness (AHR) / Asthma

Model Species Top Tier Data

House Dust Mite (HDM)

Mouse

  • Direct pulmonary Mechanics (Methacholine Challenge – FlexiVent)
  • Bronchoalveolar Lavage Fluid (BALF) cell differential, neutrophils & cytokines
  • Lung Histology (Goblet Cell Hyperplasia / Muscin Staining)
  • Serum IgE

Ovalbumin (OVA)

Rat& Mouse