Cardiovascular disease is the leading cause of death worldwide. Cardiac dysfunction has a wide range of causes and clinical presentations, typically with a high degree of medical complexity. PBI studies cardiovascular disease in an integrative manner by evaluating physiological & biomarker parameters ranging from cardiac & systemic hemodynamics, renal function and ex vivo vascular function. Together, these data provide a detailed view of the clinical potential of test compounds. PBI offers an array of cardiovascular disease and injury models, with many models reflecting the complex cardiovascular consequences of cardiac and renal injury.test
Myocardial Infarction
Model | Species | Top Tier Data |
---|---|---|
Ischemia Reperfusion |
Rat & Mouse |
|
LAD Ligation |
Rat |
Hypertension Based Cardiac Dysfunction, Hypertrophy & Failure
Model | Species | Top Tier Data |
---|---|---|
DOCA + Salt |
Rat |
|
Dahl Salt Sensitive |
Rat |
|
ANGII ± L-NAME |
Rat |
|
Spontaneously Hypertensive Rat (SHR) |
Rat |
|
5/6 NPX + NaCl (pole resection method) |
Rat & Mouse |
|
5/6 NPX (renal infarction method) |
Rat |
Cardiac Hypertrophy , Cardiac Pressure Overload & Heart Failure
Model | Species | Top Tier Data |
---|---|---|
Transaortic Banding (TAB) |
Rat |
|
Isoproterenol |
Rat & Mouse |
|
Phenylephrine |
Rat & Mouse |
|
ANGII (±L-NAME) |
Rat & Mouse |
|
Myocardial Infarction (LAD Ligation) |
Rat |