Diabetes and metabolic disorders introduce systemic insults, leading to significant cardiac, renal and liver disease. With an increasing worldwide incidence of obesity and diabetes, cardiac, renal and pulmonary dysfunction secondary to metabolic disorders are of critical interest in modern biomedical research.
Modulating central regulating factors allows PBI to fine-tune each model system for target expression and to drive more complex histopathological presentation. Disease severity and systemic complications may be exacerbated by manipulating salt intake (high salt feeding), interfering with endothelial function (L-NAME in drinking water) or reducing renal mass.
Type 1 Diabetes
Model | Species | Top Tier Data |
---|---|---|
Streptozotocin (±NPX) |
Mouse (Rat – Under Development) |
|
Type 2 Diabetes
Model | Species | Top Tier Data |
---|---|---|
ZSF-1 (±NaCl, ±NPX) |
Rat |
|
Zucker Diabetic Fatty (ZDF) Rat |
Rat |
|
db/db Mouse (±NPX) |
Mouse |
|
BtBr Mouse |
Mouse |
Metabolism & Diet
Model | Species | Top Tier Data |
---|---|---|
High Phosphate/Calcium Diet (±NPX) |
Rat |
|
High Fat Diet |
Rat & Mouse |
|
High Carbohydrate Diet |
Rat & Mouse |