Renal dysfunction resulting from acute kidney injury (AKI) and chronic kidney disease (CKD) is a prevalent clinical condition for which there is a need for effective preventative and therapeutic strategies. Whereas AKI is typically abrupt in nature, CKD develops gradually over time causing a progressive deterioration in renal function. Although temporally distinct, AKI and CKD are closely related and interconnected, with each syndrome representing a risk factor for the other. Furthermore, both AKI and CKD are linked to other clinical disorders such as hypertension and heart disease resulting in cardiorenal syndrome. PBI offers a wide array of animal paradigms that model human conditions of AKI and CKD, including acute renal failure, acute and chronic renal ischemia/reperfusion, nephrotoxicity, and diabetic nephropathy.
Acute Kidney Injury & Failure (AKI / ARF)
Model | Species | Top Tier Data | |
---|---|---|---|
Unilateral Ureter Occlusion (UUO) | Rat & Mouse |
|
|
Renal Ischemia/Reperfusion (I/R) | Rat & Mouse |
|
|
Glycerol Induced Rhabdomyolysis | Rat |
Nephrotoxicity
Model | Species | Top Tier Data |
---|---|---|
Cisplatin |
Mouse |
|
Acute Streptozotocin |
Mouse |
|
Puromycin (PAN) |
Rat |
Chronic Kidney Disease & Renal Insufficiency
Model | Species | Top Tier Data |
---|---|---|
Renal Ischemia/Reperfusion |
Rat & Mouse |
|
5/6 NPX + NaCl (pole ablation method) |
Rat & Mouse |
|
5/6 NPX (renal infarction method) |
Rat | |
DOCA + Salt |
Rat | |
ANGII + L-NAME |
Rat |
Autoimmune Kidney Injury
Model | Species | Top Tier Data |
---|---|---|
Nephrotoxic Serum Nephritis (Anti-Glomerular Basement Membrane Ab) |
Mouse |
|
Passive Heymann Nephritis (Anti-Fx1A ab) |
Rat |
Diabetic Nephropathy
Model | Species | Top Tier Data |
---|---|---|
ZSF-1 (±NaCl, ±NPX) |
Rat |
|
Zucker Diabetic Fatty (ZDF) Rat |
Rat | |
db/db Mouse (±NPX) |
Mouse | |
BtBr Mouse |
Mouse | |
Streptozotocin (±NPX) |
Mouse
(Rat – Under Development) |